Modeling Hematological Diseases and Cancer With Patient-Specific Induced Pluripotent Stem Cells
نویسندگان
چکیده
منابع مشابه
Modeling neurological diseases using patient-derived induced pluripotent stem cells.
Reprogramming of somatic cells to an embryonic-like state has dramatically changed the landscape of stem cell research. Although still in its formative stages, the field of induced pluripotent stem cells (iPSCs) has the potential to advance the study of neurodegenerative and neurodevelopmental disorders at the molecular and cellular levels. The iPSC technology could be employed to establish in ...
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The generation of induced pluripotent stem cells (iPSCs) has opened up a new scientific frontier in medicine. This technology has made it possible to obtain pluripotent stem cells from individuals with genetic disorders. Because iPSCs carry the identical genetic anomalies related to those disorders, iPSCs are an ideal platform for medical research. The pathophysiological cellular phenotypes of ...
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1 Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2 Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4 Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, Unit...
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Regenerative capacity of mammals is limited and can rarely regenerate a specific organ or tissue fully. Due to these limitations, regenerative medicine seeks efficient and safe cell sources for regeneration of damaged tissues and organs or treatment for incurable diseases. Human embryonic stem cells (HESCs) hold two important properties called self renewal and pluripotency. However, the use of ...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2018
ISSN: 1664-3224
DOI: 10.3389/fimmu.2018.02243